Septran DS Tablets 160/800mgSeptran DS Tablets 160 800mg Overview Septran DS Tablets 160 800mg combine Sulfamethoxazole and Trimethoprim, two powerful antibiotics used to treat and prevent a wide variety of bacterial infections. This combination therapy effectively disrupts bacterial DNA synthesis, stopping the bacteria from multiplying and spreading. How It Works Sulfamethoxazole works by inhibiting the synthesis of dihydrofolate in bacterial cells, preventing bacterial growth.