Mupirocin (Muprivex 5g)Indications and Dosage Clean and dry the affected skin area. Apply a small amount of mupirocin topical to it with a cotton swab or gauze pad as directed. Mupirocin ointment l is usually applied 3 times per day for 10 days. Use only a small amount of the medicine. You may use a sterile gauze pad to cover the treated skin. Do not cover treated areas with a bandage, plastic wrap, or other covering that does not allow air to circulate. Do not spread