Naftifine Gel (Naftifine Hydrochloride) 2% Antifungal 60 grams (RX)Naftifine Gel (Naftifine Hydrochloride) 2% is a topical antifungal medication designed to treat a variety of fungal skin infections. This medication works by disrupting the formation of the fungal cell membrane. This disruption of operation blocks production of enzymes and stops oxygen transfer which allows the body to clear up the infection. Since the medication remains on the top layer of skin, it works for extended lengths of time in between