Isotretinoin 10mg (Acnetrex)Indications and usage Isotretinoin is a retinoid for systemic treatment of acne. It is indicated for severe forms of cystic acne and acne conglobata, especially when the lesions involve the trunk. Isotretinoin is also effective in correcting severe keratinization disorders. However, longer periods of isotretinoin therapy may be required, thus increasing the risks of side effects, including skeletal changes and cardiovascular complications.